Seray and Lukas in Lucideon’s Information Centre.

Open Access publications from HyMedPoly Researchers

The first successful outcomes of Lukas Gritsch, ESR3 project “Biodegradable and Bioresorbable Polyesters”, and Seray Kaya, ESR7 project “Antibacterial mesoporous bioactive glass (MBG)”, were recently published with open access in renowned international journals.

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Early Stage Researcher Lukas Gritsch has co-authored two papers with Christopher Lovell, Wolfgang H Goldmann and Aldo R Boccaccini

The first article, entitled “Fabrication and characterization of copper(II)-chitosan complexes as antibiotic-free antibacterial biomaterial” is one of many successful achievements of the collaboration between the Institute of Biomaterials at the University of Erlangen Nuremberg and Lucideon. It was published in September 2017 by Elsevier’s journal Carbohydrate Polymers and it is available for download here: .

In the paper the use of chitosan as a natural carrier for the therapeutic delivery of copper is reported. Chitosan was selected because of its known ability to chelate heavy metal ions. Moreover, chitosan has several beneficial properties such as high biocompatibility and regulation of blood coagulation. The role of copper in angiogenesis and bacterial inhibition, if appropriately engineered, can be used to deliver ad hoc therapies to promote wound healing  (e.g. in diabetes foot ulcer) as well as in scenarios where an antimicrobial effect is needed to address the issue of drug-resistant bacteria.

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In February 2018 the same authors also published a short paper “Do bioresorbable polyesters have antimicrobial properties?” on the Journal of Materials Science: Materials in Medicine. This rapid communication thoroughly scrutinises the hypothesis of the intrinsic antibacterial activity of a number of widespread biomedical polymers. Link to full paper:

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The research group is now focusing on an extensive investigation of the combination of polyesters with antimicrobial chitosan and its fabrication using several techniques (e.g. electrospinning and additive manufacturing). The dissemination of the outcomes of these studies is planned to happen in the second half of 2018.

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Early Stage Researcher, Seray Kaya (ESR 7) says “Our recent publication is a review paper published in the journal of “Materials Science and Engineering: C” on 1 February 2018. The review “Mesoporous silica-based bioactive glasses for antibiotic-free antibacterial applications” is based on literature studies of the antibacterial activity of sol-gel derived drug-free metallic ion doped SiO2-CaO and SiO2-CaO-P2O5 mesoporous bioactive glasses. We have a second manuscript under review discussing the processing and characterization of drug-free antibacterial mesoporous bioactive glasses. ”

You can download the review paper through the link:

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